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When is the Best Time to take my Supplements

When is the Best Time to take my Supplements?

Most of us take more than one supplement and many of us take one or more prescription drugs. One of the most frequently asked questions  concerns the timing of medications and supplements and it can be very confusing.  To make matters worse, some of the labels of supplements make no sense at all telling us to wait 2 hours before or after a meal or in one case two manufactures of the exact same product have totally different directions. The product, Genacol, used for arthritic and joint pain recommends 3 capsules on an empty stomach either last thing at night or first thing in the morning. Their competitor, Nutri-Collagen recommends 2 in the morning and two in the evening with food. How far apart can you get?

In this article I will try and explain the reasons for taking supplements or drugs with food, on an empty stomach and how many prescription drugs can interfere with the absorption of your supplements.


I start with Calcium because most of your inquiries are about Calcium and the warnings on the bottle that it can interfere with other supplements and medications.

In the first place Calcium supplements of all kinds MUST be taken with food. If you take your calcium supplement on an empty stomach you will actually run the risk of getting kidney stones. This happens because calcium taken on an empty stomach is eliminated through the kidneys. If your body is deficient in Calcium your kidneys will not allow your body to eliminate the calcium. The free floating calcium ions attach themselves to oxalates from other foods and form calcium oxalate stones in the kidney. When you take your calcium supplement with food it will be excreted in the feces and not wind up in your kidneys where it can form stones.

Calcium is also taken with food because of its potential to upset the stomach and calcium is usually combined with Vitamin D to transport it to where it is needed and magnesium to reduce the possibility of constipation, a side-effect of calcium.

When you make a plan about how you are going to take your supplements and prescription medications, you have to start with calcium taken at mealtime.


Now that you have decided to take your calcium with a meal suppose you also have to take an anti-inflammatory drug such as naprosyn with a meal but you know that calcium will interfere with the absorption of all medications especially if it is calcium carbonate. The carbonate form of calcium is also known as Tums a product that absorbs stomach acid along with almost anything else it comes in contact with.

If you take them together, your naprosyn becomes bound up in the calcium and it may take an hour before the calcium ions and the carbonate molecules are broken off by your stomach acid releasing the naprosyn into your bloodstream. You have simply delayed the process but you have not lost any of the potency of your prescription drug.

If you do have to take a number of prescription drugs in the morning you take them first thing along with your supplements and then at least one-half hour later you take your calcium with breakfast. This time gap allows the supplements and prescription drugs to leave your stomach before you eat food and take your calcium.

Many of you take prescription drugs that reduce acid output in your stomach such as Losec, Nexium, Prilosec or Pariet. These drugs interfere with the absorption of nearly all supplements, prescription drugs and calcium and should be taken about one hour after your calcium supplement, allowing everything before it to be dissolved in your bloodstream.


Most prescription medications and supplements work better when taken on an empty stomach because there are no food or drugs to interfere with their absorption. However, taking supplements on an empty stomach is not critical because if they are taken with food they simply have to wait for your stomach to empty and their absorption may be delayed by about one hour. You may lose some potency but only 10 percent of digestion takes place in your saliva and stomach so at least 90 per cent of your supplement will eventually be operating in your blood stream.


Most supplements such as multivitamins, Vitamin C, B Vitamins and calcium magnesium products are water soluble. This means that the individual dose will only last in your body for 4 to 6 hours. That means if you have a vitamin that requires you to take 3 a day, you must divide the dosage over the whole day. Taking 3 at once will do you no more good than taking one. This holds true for glucosamine supplements that must be taken 3 times a day and calcium supplements that must be taken two or three times a day. Water soluble supplements are usually recommended to be taken on an empty stomach, unless of course it is calcium.


Fat soluble supplements include Vitamin D, Vitamin E, fish oil and most forms of Coenzyme Co Q10. These supplements are delivered to the fat tissues of your body and stored there to be used when needed. This means that if you take 2 fish oil capsules a day, or two Vitamin D capsules a day you can actually take them together and not have to divide up the dose. They will be stored and released as needed when your body needs them. Coenzyme CoQ10 also dissolves in the fat tissues but lasts only about 12 hours. This means that if you are taking CoQ10 as an antioxidant for energy then one a day is enough. However, if you are taking CoQ10 for your heart then you should divide the dosage you take by taking one capsule every 12 hours.

With fat soluble products food in your stomach is not a factor. They can be taken with or without food and they will still arrive in your fat tissues ready to be released. However, once again, calcium interferes with everything and you always have to take your medications and supplements away from your calcium if possible.


Reactions between supplements and prescription drugs are really quite rare because of the very different ways your body treats these substances. When you swallow a prescription drug your body has no idea what to do with it. Your body then treats the drug as a foreign substance and sends it to the liver to be detoxified and rendered harmless. However prescription drugs are designed in such a way that when this process takes place in your liver it actually activates the drug and sends it out into your bloodstream to do its work. After 4 to 8 hours (the half-life of the drug) the remaining half of the drug is returned to the liver and the process is repeated sending a new active form out into the bloodstream.

When your body swallows food or supplements they contain recognizable ingredients that your body breaks down into nutrients. These substances are digested by your saliva, stomach acid and broken down into their component parts by enzymes in your upper and lower intestine. These ingredients are then transported to the different cells that require these ingredients.

Because these two processes are extremely different it is highly unlikely that any drugs and supplements interfere with each other. St.John’s Wort is one exception because it is detoxified by your liver by the same substance (cytochrome p450) that detoxifies drugs. Grapefruits are also detoxified at the same site and may also interfere with some medications.

The bottom line is that almost every drug interferes with every other drug because they are all detoxified at the same site in your liver. The worst culprits are Coumadin (warfarin) and Tylenol because they take longer to detoxify than most drugs and slow down the absorption of all the other drugs trying to get through the liver and into your blood stream.


I am going to create a drug and supplement profile for a typical elderly patient and try and show how that patient should be taking their prescription medications and their supplements.

A typical elderly person will take one or two meds for blood pressure, a diuretic along with these to further control their blood pressure and a cholesterol-lowering pill. My fictional patient will also be a female who takes fosamax for her bones and omeprazole to control her acid reflux and naprosyn 500mg twice a day for her arthritis.

On the supplement side she takes a calcium magnesium supplement, a multiple vitamin, fish oil, Vitamin D, Vitamin E and CoEnzymeQ10.

Morning: Before breakfast on an empty stomach she takes her blood pressure meds, her diuretic, one multivitamin, 2 fish oil capsules, 2 Vitamin D capsules and one CoenzymeQ10.

After having her morning coffee or tea, about 1/2 hour after taking her other meds she eats breakfast and takes her calcium supplement. About one hour after breakfast she takes her stomach medicine (omeprazole). Sure it would be better to take your stomach medicine first thing and avoid any stomach upset but this drug is very dangerous and interferes with the absorption of most other drugs including all her meds and her calcium.

Lunch: Our patient takes her calcium and her naprosyn with her lunch. The naprosyn, if taken in the morning would reduce the effectives of her blood pressure medications and so by taking it with lunch that contraindication is avoided but it will be about 2 hours before it begins to work.

Supper: One again we take the calcium supplement and she can also take her second capsule of Coenzyme Q10 because it is fat soluble and food will not interfere with it. After supper is finished she takes her cholesterol tablet which will be far away from any interaction with grapefruit and which must be taken in the evening because your body does not produce cholesterol until you go to sleep. Sometime later in the evening with a small snack she will take her 2nd naprosyn tablet and if she takes fosamax once a week, she will take it on an empty stomach first thing in the morning about ½ hour before breakfast because she should be upright for that ½ hour to prevent any damage to her esophagus after taking the fosamax.

If you think this regimen is confusing you are absolutely right.  If you try and work out a schedule with your pharmacist they probably will be more helpful than your physician who blames every interaction on supplements. If you want to be absolutely sure you are doing the right thing you bring your list into me and I will help you organize your supplement and medication schedule. There is no charge for this service but you must make an appointment.

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24 Responses to When is the Best Time to take my Supplements

  • Thanks for the input and examples in your article you wrote here.I am nearing 50, female, and in my 40’s (42), I started having HPB (high blood pressure) issues. The readings were not too bad, but because I’m adopted and didn’t no about family history until I was into adulthood, I only found out HBP ran on the maternal side. I didn’t know much about the paternal side, and isn’t know anying about the health history so I had to fly by the seat of my pants…
    Anyway, I was put on dyazide at first. It helped but the diastolic number kept wanting to get closer to 90, was averaging lower 80’s.
    ***I should mention that 4 days before I was to turn 39, my OB/GYn at the time found stones in my gallbladder, and my total triclycerides were at 298. I was having troubled with the pain of the stones so the gallbladder was removed and my totals went down to 150, and with exercise I got it back to 100, but my HDl & LDL never really wanted to behave themselves, so I figured here we go I have the double whammy…maternal side heart issues and the paternal side cholesterol issues.***

    Back to the the story….anyway for the blood pressure I was given dyazide, and then I found out the maternal side, the type of heart attacks the family members had were myocardial infarctions. So my doctor prescribed imdur (I forget the generic name). He also prescribed it because my diastolic levels were rising to 90 and then some (I’m Irish, we jump with our blood pressure from 0-1000 in a split second, lol). So here I am on dyazide, imdur ( i was having angina on the right side of my jaw, I had long extensive testing done (nothing confirmed bad) and my doctor wanted me on the imdur to be safe since the myocardials ran in the family) and I’m asthmatic so I take Advair.
    ***(former smoker so this was my gift to myself, and for those of you out there I had quit for 17 years, and picked them up for 8 months and bam, I had asthmatic bronchitis, therefore leaving me with asthma…. If you quit just cold turkey them.. I did it twice…17 years and then after the asthma diagnoses, I cold turkeyed them again, the BEST way tot do it…smoke free to this day and it’s been 8 years and won’t go back because if you get asthma and you feel how it is not to breathe, you’ll never picked them up again)***

    Then one day my blood pressure reading went to 180/105… I knew something had been wrong for about 3 days. Now females listen up. It is true that women have different symptoms then men. I tried everything to be none stressed. I had the tightness in my jaw…I had the uneasiness of a slight burning between my shoulder blades, BUT no tightness running through the arms, or
    weakness in extremities. Just a tired, odd feeling between shoulder blades and tightness in the jaw I said I’m going to the fore station near me and get a reading…they have EMT/paramedics there and setting not he ermergency room will cost a future and take forever to me seen and it was 11:30 pm. So the firehouse guys were so sweet, and I had to wake them..I felt so bad and kept apologizing….they assured me no problem. I told them my BP meter at home was giving me off the chart readings of 180/105… Then he listened and his reply was…so where would hospital you like the ambulance to drive you to. He then said I’m getting the reading you did, and they use sthescopes so I knew their readings were on the money.
    They said we can’t let you leave here drive yourself with a BP like that because you could stroke out or have a neath attack and pass out driving and hurt someone. I agreed with them…so off to the hospital for tests, all over nights and all conformed fine.
    Then my doctor prescribed me Verapamil ER. All in all they have been doing a great job….

    Now here comes the fun part (not so great, but a blessing in disguise). My levels on the cholesterol started to rise I tried Lipitor but my body had the reaction, like some people do, of the muscle weakness and tightening up, so I couldn’t take that. So we tried Niacin, Not Niaspan. The niacin worked great, until it spiked my sugar readings and I’m not diabetic, so off another medication. I watched what I ate, and my levels went down to safe readings.

    Now here we go…last year in October I had been playing the prior past months tennis everyday, and somedays I felt heaviness in my legs but I was thinking of course I would I’m playing 1 1/12 hours everyday, and I hadn’t played since I was 12 pounding the courts. I decided to change up because I had been swimming and thought I’d mix up my routine. So I’m 6 months I to tennis an October 2010, I got off the courts went home and had noticed the whole month I felt like my lower left calf had a strain in it, not sprain. So I would do the icing and heating (not in that order exactly) and had had 2 charley horses, which I never get in that left leg. So I decided to call my doctor and his wife is a nurse and works there too, so she said come in now so we can check the leg. The doctor looked at it, and felt it, and said we need to get a Doppler on that leg, and 2 days later as I was getting the Doppler done, it was confirmed I had a DVT (Deep Vein Thrombosis) in my mid area of the left calf.
    So here I go again, another problem, when in actuality it was a blessing it was confirmed. I’m now on warfarin, 2 different doses, alternating days… And believe it or not, I can tell when my blood is too thick or too thin. I keep a mental note of what I’ve eaten for the week, and this is how it helps so much to control. I’ve had many scares of having to go to the ER because of maybe the clot moved but if in lower extremities changes of that are not as likely to become a pulmonary emboli/embolism, but I get checked if INR is super low and my breathing is very heavy for me. Everyone is different. I watch my vitamin K intake.
    To make matters worse, I’m in peri-menopause stages and because of losing blood due to fibroids, and I’m high risk for a DNC, I had the Mirena IUD placed and it has helped so I can get my INR readings normal. I was so anemic because of going through change of life and my blood not right because of being on warfarin that it was hard to control. All better in this area now.

    How here is why I posted this lengthy post..first off it may help someone, and save there life…or be information they were looking for. Anyway, because my cholesterol readings are not good, my doctor wants me to take 1200mg – 2 times a day of FishOil (omega 3). Fish oil is known to thin the blood, so I’m curious if I should start with 1200 daily for a week and get an INR reading done to see how my blood is doing with the warfarin and fish oil first before jumping right into the 2400mg’s daily, as what he wanted me to do. Last week my INR was 2.2, which I’m happy with.
    I would also like to know, when is the best time to take fish oil supplement if a person is on warfarin. I take my warfarin, 6pm everyday. I would be appreciative is someone could answer this for me.

    Thanks, and hope this post helps people out there. I hope someone has an answer for me.

  • My husband has been diagnosed with pancreatitis, will he get worse over time with this disease, is there hope?

  • When is the best time after 1000 mg of calcium to take Vit d, fish oil, milk thistle, probiotics, chhitosan. Or does it matter with these particular supplements?

  • What is the digestion time for chitosan capsules or tablets which seem to end up in the tolet undigested?

  • What spice in my cabinet is best to make a tea out of for bloating from just about everything including weggies that I eat?

  • anise, parsley, or gentian. Are these in the same family?

  • Is the timing of Chitosan and/or Glucomannan before meals very important?
    Which one of these is the best for weight management. Or am I throwing my money away?

  • i have had some good response from you before so here is another question,,,,,,,, i take a multivitamin and vit E every day with all the rest of my cocktail o f stuff like prescription and supplenment so what about the vit E and mutivitamin , when can i take them also ,i am in a wheelchair so its a lot to digest ………… thanks

  • Thank you, Barry for the most valuable information.


  • Hi Barry
    I LOVE this article. I struggle trying to figure out when to take what med with what..etc. Are you saying I can send you a list of my meds an you will help me? And, if so, do I do it through here?

    Thanks for this article and anything you can do to help me..

  • How long after taking collagen supplements should I eat? I take them in the morning before breakfast, and again at night. I often want a late night snack after.

  • I take Vita Pulse (C0Q10, NAC, and PQQ Na2) and levothyrozine on an empty stomach. After breakfast, I take a multi, B6, B12, magnesium, niacin, C, calcium, probiotic, E, D3, and krill oil.

    Should I take the after breakfast ones at scattered times?

  • I am curious: Would it be beneficial to split the 2 tablet slow release calcium intake into one in the morning (with breakfast) and one at night (with dinner) instead of 2 tablets in the morning?

  • loved your article……i needvmorevhelp becausebi take a thyroid pill beside the BP meds and i have been taking a teaspoon of honey first thing in the morning…and also live for my coffee. also take lipitor and calcium pills. help. i forget to eat working out the supplements in between. i have Lpr and chew gum constantly to relieve symptons. appreciate your feedback. so fed up.

  • Always take calcium with a meal and take your Lipitor between supper and bedtime. If you suffer muscle pain, then discontinue Lipitor

  • Yes. It would work better

  • Your calcium should always be taken with food. The rest can be taken an hour away from your calcium

  • Your snack will not interfere with the collagen supplement

  • I see you will moderate this, so perhaps I can ask a question too: Is it a bad idea to take liquid calcium and magnesium with a clear fruit juice (typically tart cherry or pomegranate) while on a 7-14-day fast? I cramp up badly a few days in if I don’t get electrolytes.

  • Most of my supplements need to be taken on an empty stomach can I take them together? They include IP6, probiotic, NAC, serrapeptase. My only med is Metformin. Thank you for your help.

  • Not a problem taking them altogether

  • Definitely take your calcium with the juices to avoid the cramps

  • Co Q -10…Am or Pm…taking it for heart and enegery?
    Thank you!

  • both

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